[International] Stem Cell Treatment blocked Age-related ‘Macular Degen…


US research team blocked age-related macular degeneration progress by embryonic retina cell transplant.

Dr. Amir Kashar team of Roski Eye Institute of US Southern California University differentiated embryonic cell into RPE, and transplanted to age-related macular degeneration patients. And finally it is reported to Medical Express and Health day News on 4th (Local time) that they succeed to stop the progress of age-related macular degeneration.

RPE is the tissue to help retinal sensitizing cell photoreceptor at the center of macular. Macular degeneration occurs when this part got damaged. Research team planted RPE on super-thin sheet to transplant to 4 progressive macular degeneration patients, and observed for a year. As a result, all 4 patients stopped the progress of macular degeneration, and some of them had improved their sight.

One patient read more letters than do the surgery, and 2 patients improved the macular function which is available to look at certain points. It was the proof of RPE engraftment into macular tissue. So this is the very important part of macular degeneration treatment, said Dr. Kashani.

There was no side effects or unexpected problems appeared. Adverse rejection was not shown to the patients with small amount of immunodepressant. Dr. Kashani explained that immune system do not attach brain or brain related tissue. Research team is planning to progress 1 phase clinical trial.

Age-related macular degeneration is the disease to lose central vision by damaged central point of macular. There is no way for full recovery, but only antibody injection or laser surgery can delay the progress. If it is neglected, it can lead to lose one’s sight.

There are two types, dry or wet, and most of them are dry type. Wet type has faster progress than dry type, and generated abnormal blood vessel which occurs bleeding so that it requires urgent treatment.

This research result is reported to latest version (April 4th) of ‘Science translational medicine.’